Abstract
The lungs, responsible for crucial respiratory functions such as gas exchange and protection against airborne infections, are intricate organs comprising the trachea, bronchi, bronchioles, and alveoli. To gain comprehensive insights into respiratory diseases, inhalation toxicity, and infectious agents, it is imperative to understand the complex cellular composition, structure, and molecular signature of the human lung. While animal models have been extensively used, their differences from the human lung necessitate the development of an in vitro model that faithfully represents human lung physiology. This study introduces a novel approach using human pluripotent stem cells to establish a human lung organoid model.
The advantages of the human lung organoid model are manifold. It offers a more accurate representation of human lung physiology. The versatility and reproducibility of this model enable researchers to investigate a wide range of respiratory diseases and explore personalized medicine approaches. Additionally, the organoid model facilitates the assessment of the toxicity of inhaled substances, contributing to the development of safer products and environmental policies.
In conclusion, the development of a human lung organoid model represents a significant advancement in respiratory research. This innovative model faithfully recapitulates the cellular diversity and architecture of the human lung, providing a valuable tool for studying respiratory diseases, inhalation toxicity, and infectious agents. By deepening our understanding of lung pathophysiology, this model holds promise for the development of effective therapeutic strategies and interventions, ultimately improving respiratory health outcomes.
BioSketch
2021–present Principal Investigator, Stem Cell Convergence Research Center, KRIBB
2020–present Professor, Department of Functional Genomics, UST
2012-2020 Research Scientist, Stem Cell Research Center, KRIBB
2009-2012 Ph.D. in the Department of Biomedical Science, CHA University