Abstract
Metastasis is defined as “spread of cancer cells to other organs.” Metastasis accounts for over 90% of cancer-related deaths and there are no effective treatments for metastatic cancer patients. Metastasis process comprises of several steps including invasion, intravasation, survival in circulation, arrest at a distant organ, extravasation, and formation of micro/macro metastases. In order for cancer cells to survive and grow in a new organ, cancer cells should be able to adjust to and exploit the specific tissue environment and this is achieved by constant communication between cancer cells and non-cancer cells within the specific tissue environment.
In this presentation, cancer cell-microenvironment communication in breast cancer metastasis will be discussed. Specifically, the role of O-linked glycosylation enzyme GALNT14 in lung metastasis of breast cancer and that of c-MYC in brain metastasis of breast cancer will be presented, with the focus of their roles in modification of organ-specific tumor microenvironment.
BioSketch
Current position
Associate professor (Tenured), Department of Biological Sciences, KAIST

Research training
[1999 - 2004] Ph.D. in Biochemistry, Molecular and Cell Biology, Cornell University, NY
[2005 - 2007] Postdoctoral fellow at Amgen Inc. South San Francisco, CA, USA
[2007 - 2010] Research fellow at Memorial Sloan-Kettering Cancer Center, NY, USA

Selected publications
• Jae Eun Lee and Mi-Young Kim (2021). Cancer Epigenetics: Past Present and Future. Seminars in Cancer (online ahead of print).
• A-young Yang, Eun-bee Choi, Mi So Park, Seon-Kyu Kim, Min Seok Park and Mi-Young Kim (2020). PARP1 and PRC2 double deficiency promotes BRCA‐proficient breast cancer growth by modification of the tumor microenvironment. FEBS J.
• Beom Jin Hong, Woo Yong Park, Hwa-Ryeon Kim, Jin Woo Moon, Ho Yeon Lee, Jun Hyung Park, Jae Seok Roe, Seon Kyu Kim, Young Bin Oh, Jae-Seok Roe and Mi-Young Kim (2019).Oncogenic KRAS sensitizes lung adenocarcinoma to GSK-J4-induced metabolic and oxidative stress. Cancer Research, 79, 5849–59.
• Ho Yeon Lee, Junghwa Cha, Seon Kyu Kim, Jun Hyung Park, Ki Hoon Song, Pilnam Kim, Mi-Young Kim (2019). c-MYC derives breast cancer metastasis to the brain, but promotes synthetic lethality with TRAIL. Molecular Cancer Res, 17(2):544-554.
• Ki-Hoon Song, Mi So Park, Tulip S. Nandu, Shrikanth Gadad, Sang-cheol Kim and Mi-Young Kim (2016). GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment. Nature Comm.7, 13796.
• Eun-bee Choi, A-young Yang, Sang Cheol Kim, Jungsul Lee, Jyung Kyun Choi, Chulhee Choi and Mi-Young Kim (2016) PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. Oncogene. 35(35). 4569-4579.
• Woo-Yong Park, Beom-Jin Hong, Jungsul Lee, Chulhee Choi, and Mi-Young Kim (2016).
H3K27 demethylase JMJD3 employs the NF-kB and BMP signaling pathways to modulate the tumor microenvironment and promote melanoma progression and metastasis. Cancer Res. 76(1), 161-170.